Stroke, Ischemic
About the Disease
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism
Common Targets
G2740 | G5724 | G3131 | G5743 | G824 | G26168 | G8564 | G100616448 | G3785 | G2161 | G4256 | G126075 | P16740 | G406920 | G80055 | G105375175 | G6934 | G2904 | G4883 | G8029 | G100616473 | G55328 | G148811 | G3767 | G406891 | G8986 | G1773 | G7292 | G22900 | G246 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Superoxide dismutase (SOD) (nonspecified subtype) | G6558 | G401265 | G4524 | Phosphodiesterase (nonspecified subtype) | G1588 | G115004 | G406941 | G4312 | G100616486 | G2950 | G6331 | G5052 | G3162 | G6326 | G6916 | G54575 | G948 | G847 | G116511 | G128674 | P6747 | G5624 | G106144586 | G1071 | G132 | G6401 | G221692 | G7422 | G11173 | G4023 | G406942 | G4982 | G5028 | G840 | G6000 | P36692 | G65078 | G4040 | G8775 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | G407037 | G23255 | G5294 | G338557 | P13024 | G6548 | G574410 | G11255 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | G196463 | G7515 | G5243 | G1576 | G7450 | G774 | G5023 | G5599 | G1499 | G22827 | G4915 | G3108 | G12 | G6647 | G1909 | G4353 | G7186 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G6714 | G50617 | G5144 | G8514 | G266977 | G2859 | G165904 | G7508 | G2643 | G8882 | G6196 | P5768 | G406984 | G51284 | G51738 | Kainate Receptor (GluR) (nonspecified subtype) | P5760 | G79875 | G149951 | G692198 | G197320 | G4804 | Calpain (nonspecified subtype) | G3586 | G6499 | G3949 | G800 | G100126350 | G3827 | G4854 | G3240 | G5879 | G401494 | G7276 | G23293 | G2701 | G5789 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | G2288 | G552 | G9519 | G57662 | Voltage-gated K(v) channel (nonspecified subtype) | G7511 | G5802 | G627 | G25 | G2897 | G10347 | G9536 | G114548 | G6487 | G4514 | G51185 | G6261 | G6571 | G4157 | G2162 | G3119 | G57458 | P6176 | G116519 | G1373 | G10658 | G26034 | G9970 | G57608 | G3576 | G63826 | G3738 | G1200 | G682 | G7187 | G2902 | G2915 | G60674 | P18508 | G57091 | G9722 | Cyclophilins (nonspecified subtype) | G6423 | G169792 | G7512 | G285965 | G7482 | G5447 | G361 | G84876 | G5733 | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | G3593 | G1565 | G283208 | G3673 | G23225 | G23294 | G6337 | Tyrosine-Protein Kinases Src (nonspecified subtype) | G6608 | G5594 | G5739 | G3717 | G191 | G4842 | G5029 | G2784 | G283638 | G130507 | G241 | G148 | G1445 | Interleukin-1 (nonspecified subtype) | G3958 | G407040 | G84830 | G5321 | G100422959 | G59341 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | G3551 | G1815 | G4986 | G100422966 | G10786 | G10800 | G9652 | G3557 | G6197 | G1557 | G7058 | G2312 | G7015 | G2263 | G2811 | G3674 | G7124 | G22839 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | G79001 | G84649 | G11343 | G183 | G79939 | G553 | G574449 | G1902 | G9370 | P5859 | G406947 | G10013 | P5755 | G23607 | G105375733 | G57142 | G3786 | P6463 | Phospholipase A2 (nonspecified subtype) | G5334 | G3386 | G3620 | G2180 | G8395 | G3111 | Steroid 5-alpha-Reductase (nonspecified subtype) | G2053 | G239 | G259 | G10014 | G574452 | Hedgehog Protein (nonspecified subtype) | G59277 | G3725 | G759 | P11019 | G1282 | G801 | G23510 | G5137 | G5600 | G3613 | G4535 | G221037 | G51564 | G100130015 | G3091 | G187 | G727 | G9446 | G326625 | G6093 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G6774 | G4988 | G100313779 | G578 | Heat shock protein 90 (nonspecified subtype) | G574453 | G3274 | G771 | G9693 | G3484 | G65264 | G6581 | G80350 | G1153 | G693181 | G10280 | Alpha-2 Adrenergic receptors (nonspecified subtype) | G4314 | G1128 | G6352 | Ribonucleoside-diphosphate reductase | G308 | G3479 | IL-1 Receptor (nonspecified subtype) | G1636 | G1991 | G102724428 | G574456 | G406906 | G54984 | G3360 | G116931 | G846 | G10428 | G9373 | G6300 | G3776 | G4815 | G50507 | G146512 | G406935 | G7018 | G217 | G842 | G3932 | Alcohol Dehydrogenase (nonspecified subtype) | G415116 | G51324 | G3988 | G407041 | G27258 | G5465 | Integrin Receptor (nonspecified subtype) | Calcium channel (nonspecified subtype) | G4049 | G7189 | G2152 | G4899 | G2814 | G5728 | G1269 | G3553 | G1432 | G4321 | G80216 | G5157 | G6943 | G55743 | Lipoxygenase (nonspecified subtype) | G3566 | G7040 | G1191 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | G160287 | G5152 | G1020 | G5687 | Glutamate Transporter (nonspecified subtype) | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | G1665 | G9698 | G114822 | G118 | G3577 | G6868 | G84439 | G8600 | G5740 | Myosin Class II (nonspecified subtype) | G6536 | G84722 | G2243 | G24145 | G9817 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | G25902 | G57153 | G3569 | G693190 | G2100 | G345 | G1558 | Opioid receptor (nonspecified subtype) | G57447 | Neurotrophic Factor (nonspecified subtype) | Chloride channel (nonspecified subtype) | Raf kinase (nonspecified subtype) | G4598 | G463 | G51422 | G554 | G2159 | G775 | G255738 | Guanylate cyclase (nonspecified subtype) | G3350 | G134 | G650157 | G79054 | G9620 | G7412 | G5175 | G105374207 | G3156 | G5795 | G6530 | G5604 | G613 | P24881 | G10979 | G6098 | G4780 | G23411 | G929 | Adenosine deaminase (nonspecified subtype) | G1813 | G4552 | G4878 | G6772 | G4734 | G100379251 | G2876 | G3753 | G10747 | G100048912 | G8856 | G6356 | G406907 | G1139 | G406991 | G1910 | G51529 | G5241 | G100 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | P6058 | G19 | G1952 | G407042 | G26040 | G8630 | G3383 | G6403 | G3748 | G7936 | G3106 | G590 | G673 | G2122 | G7852 | G81669 | G55063 | G835 | G5583 | G9448 | G130814 | Estrogen receptor (nonspecified subtype) | G4879 | G5025 | G85481 | G93624 | G1591 | G7757 | G2646 | P6320 | G6648 | G101929423 | G1268 | G64409 | G729230 | G8701 | G119391 | G4620 | G4852 | G1742 | G5034 | G5601 | G1066 | Na+/K+-ATPase (nonspecified subtype) | G4537 | G5467 | G3486 | STAT5 (nonspecified subtype) | G131405 | G10060 | G958 | G2185 | G4599 | G5987 | G9218 | G581 | G3601 | G100130987 | G5727 | G113278 | G80128 | G9659 | G317 | 15-Lipoxygenase (nonspecified subtype) | G3741 | G6948 | G2244 | G5020 | G1361 | G6573 | G406992 | G5327 | G26769 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | P16126 | G142 | G208 | K(ATP) Channel (nonspecified subtype) | G7099 | G3973 | G83706 | G5340 | G3123 | G6262 | G64805 | G100500843 | Pyruvate dehydrogenase kinase (nonspecified subtype) | G231 | G120227 | G135 | G389816 | G6850 | G706 | G23194 | G100500858 | G9734 | G1284 | G6597 | G693212 | G4311 | G22854 | G2295 | G841 | G3605 | P40594 | G55135 | G55759 | G2147 | G497258 | G81551 | G100500878 | G2919 | sigma Receptor (nonspecified subtype) | Heme Oxygenase (HO) (nonspecified subtype) | P18298 | G140 | G1573 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | G4923 | G4985 | G5054 | G875 | G54922 | G56899 | G1123 | G1131 | G7442 | G100500912 | G5536 | G1147 | Prostanoid TP receptor (nonspecified subtype) | G4035 | G22856 | G26774 | G10008 | G54795 | G3990 | G2346 | G823 | G2730 | G100616134 | P22884 | G7498 | G5289 | G8792 | G2952 | G10724 | G104909134 | G105372028 | G378938 | G7226 | G2932 | G5742 | G5770 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | G23704 | G43 | G9429 | G3105 | P6321 | G1412 | G2057 | G5468 | G80018 | G5345 | G9379 | G9759 | G2153 | G2920 | G1577 | G6927 | G3480 | G3568 | P5753 | G5315 | G2678 | G136371 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | G6750 | G10887 | G6833 | G4322 | G1378 | G5069 | G1394 | G5105 | G55973 | Caspase (nonspecified subtype) | G51530 | G2099 | G9992 | G6484 | G50940 | G100616236 | G55605 | G1116 | G1133 | G2260 | G90288 | G55658 | G1195 | G7296 | G2264 | G2558 | G2911 | G5894 | G3630 | G145282 | G3764 | L-Type calcium channel (nonspecified subtype) | G3784 | G8673 | Sodium channel (nonspecified subtype) | G25802 | G10207 | Heat shock protein 70 (nonspecified subtype) | G55847 | G105372272 | G6469 | G6513 | G2762 | G5731 | G80142 | G51206 | G9002 | G9365 | Adenosine receptor (nonspecified subtype) | G1559 | G2321 | G27346 | G29974 | G2194 | G23235 | G836 | G57105 | G335 | G123041 | G7415 | G8529 | G3690 | G64344 | Poly [ADP-ribose] polymerase (nonspecified subtype) | G5602 | G3790 | G5444 | G98 | G140690 | G56606 | G137868 | G6427 | G41 | G1889 | G2072 | G26191 | G26802 | G89822 | G9509 | P11025 | G1555 | G100505702 | G54583 | G5819 | G6584 | G1839 | G79411 | G5328 | G4317 | G25805 | G9311 | G301 | G59067 | Neurotensin receptor (nonspecified subtype) | G3552 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | G406913 | G6915 | G7077 | G55017 | G9639 | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | G3756 | G4318 | G80279 | G2160 | G4846 | G27347 | Angiotensin receptor (AT) (nonspecified subtype) | G9208 | G10371 | G7417 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | G3579 | G375033 | G6869 | G22808 | G22926 | G4088 | G7157 | G5908 | G3707 | G150094 | G3991 | G4056 | G5494 | G6653 | G9475 | G1579 | G100616401 | G56729 | G3269 | Endothelin receptor (nonspecified subtype) | G6532 | G2266 | G64779 | G4018 | G10019 | G5605 | G57486 | G58191 | G2155 | G10856 | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | G1508 | G3818 | G51547 | G8654 | G186 | G11035 | Gamma-glutamyl transferase (nonspecified subtype) | G7490 | G338 | G351 | G185 | G4540 | G834 | G839 | alpha-Amylase (nonspecified subtype) | G83737 | G105379030 | G3146 | G3558 | P6348 | G406938 | G718 | G53354 | G10038 | G56963 | G5445 | G177 | G18 | G8505 | G375056 | G90864 | Glutamate Receptor Ionotropic (nonspecified subtype) | G4907 | Nitric oxide synthase (NOS) (nonspecified subtype) | G11318 | G3737 | G5230 | G3174 | G1728 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | G4313 | G57644 | G127602 | G54805 | G10335 | G133746 | G367 | G22871 | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | G7012 | G4233 | G4363 | G2206 | G5136 | G8974 | G8613 | G102465508 | G11103 | G1562 | G4645 | G6347 | G1401 | G1524 | G6546 | G1585 | G6506 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | G6840 | G3356 | G9252 | G5781 | G406973 | G5290 | TLR4/MD-2 complex | G25960 | G10451 | G5621 | G406919 | G2944 | G57551 | G126 | G3708 | G4048 | G2207 | G8989 | Potassium Channels (nonspecified subtype) | G7421 | G23643 | G2717 | G9718 | Rho kinase (ROCK) (nonspecified subtype) | G26212 | G284749 | G3745 | G8737 | Epoxide Hydrolase (nonspecified subtype) | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | G6195 | G4843 | G54106 | G2781 | G7013 | G7351 | G3993 | G5021 | G240 | G9388 | G574501 | G1234 | G50615 | G100126297 | G55867 | G3635 | G1901 | G5156 | P5767 | G387 | G7428 | G80854 | G112399 | G348 | G6470 | G6531 | G4129 | G4803
The "Target / Biomarker Review Report" is a comprehensive and customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about the Target(s) / Biomarker(s) of your choice related to Stroke, Ischemic, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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